探讨组配式半骨盆假体对老年髋臼周围转移性肿瘤患者的临床疗效和安全性。

回顾性分析2018年3月至2024年3月在北京大学人民医院、宁波大学附属第一医院收治的25例组配式人工半骨盆假体重建髋臼转移性肿瘤切除后骨缺损的病例资料，记录手术时间、术中出血量，随访观察术后感染、肿瘤病程、假体脱位、假体断裂等并发症。术前术后通过国际骨肿瘤协会（MSTS）功能评分评估患者症状和功能改善情况。

共纳入患者25例，其中男性8名，女性17名，平均年龄（67.64±4.84）岁。所有患者手术均顺利进行，平均手术时间和术中出血量分别为（251.80±44.79）min和（1 972.00±709.18）mL。围手术期间，2例患者深静脉血栓形成，2例出现切口感染，1例出现假体脱位。术后随访时间6~46个月，平均（25.40±11.33）个月。随访期间，3例患者出现局部复发，4例患者分别于术后6月、8月、14月、19月因原发疾病进展死亡。患者术后三个月随访的MSTS平均评分显著高于术前MSTS平均评分[20.0（18.5，25.0）vs 7.0（4.5，11.0），Z=4.286，P<0.001]。

短期随访证实应用组配式半骨盆假体重建老年髋臼周围转移性肿瘤切除后骨缺损的安全性高，并为患者获得良好的功能状态。

To evaluate the clinical efficacy and safety of modular hemipelvic prostheses in elderly patients with periacetabular metastatic tumors.

A retrospective analysis was conducted on 25 patients who underwent reconstruction with a modular hemipelvic prosthesis for bone defects following resection of acetabular metastatic tumors. These patients were treated at Peking University People's Hospital and The First Affiliated Hospital of Ningbo University between March 2018 and March 2024. Data recorded included operative time, intraoperative blood loss, and postoperative complications (infection, tumor progression, prosthesis dislocation, prosthesis fracture) during follow-up. Patient symptoms and functional improvement were assessed using the Musculoskeletal Tumor Society (MSTS) scoring system before and after surgery.

A total of 25 patients were included (8 males, 17 females), with a mean age of 67.64±4.84 years. All surgeries were successfully completed. The mean operative time and intraoperative blood loss were 251.80±44.79 minutes and 1 972.00±709.18 mL, respectively. Perioperative complications included deep vein thrombosis in 2 patient, surgical site infection in 2 patients, and prosthesis dislocation in 1 patient. The mean follow-up duration was 25.40±11.33 months (range: 6-46 months). During follow-up, local tumor recurrence occurred in 3 patients. Four patients died due to progression of their primary disease at postoperative months 6, 8, 14, and 19, respectively. The mean MSTS score at the final follow-up 20.0 (18.5, 25.0) was significantly higher than the preoperative score 7.0 (4.5, 11.0) (P<0.001).

Short-term follow-up confirms that the use of modular hemipelvic prostheses for reconstructing bone defects after resection of periacetabular metastatic tumors in elderly patients demonstrates a high safety profile and enables patients to achieve favorable functional outcomes.