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中华老年骨科与康复电子杂志 ›› 2018, Vol. 04 ›› Issue (01) : 52 -56. doi: 10.3877/cma.j.issn.2096-0263.2018.01.012

所属专题: 文献

综述

骨转换标志物在骨质疏松诊治中的分析评价及临床应用前景
马晓龙1, 刘强2,(), 吴斗2, 郑上团1   
  1. 1. 030001 太原,山西医科大学
    2. 山西大医院骨科
  • 收稿日期:2016-01-19 出版日期:2018-02-05
  • 通信作者: 刘强
  • 基金资助:
    山西省自然科学基金(2013011057-4)

Assessment of bone metabolic markers and clinical application prospect in the diagnosis and treatment of osteoporosis

Xiaolong Ma1, Qiang Liu2,(), Dou Wu2, Shangtuan Zheng1   

  1. 1. Shanxi Medical University, Shanxi DaYi Hospital, Taiyuan 030032, China
    2. Department of Orthopaedics, Shanxi DaYi Hospital, Taiyuan 030032, China
  • Received:2016-01-19 Published:2018-02-05
  • Corresponding author: Qiang Liu
  • About author:
    Corresponding author: Liu Qiang, Email:
引用本文:

马晓龙, 刘强, 吴斗, 郑上团. 骨转换标志物在骨质疏松诊治中的分析评价及临床应用前景[J]. 中华老年骨科与康复电子杂志, 2018, 04(01): 52-56.

Xiaolong Ma, Qiang Liu, Dou Wu, Shangtuan Zheng. Assessment of bone metabolic markers and clinical application prospect in the diagnosis and treatment of osteoporosis[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2018, 04(01): 52-56.

骨代谢的生化标志物是成骨细胞和破骨细胞活动而释放至血和尿中的骨基质成分,可以反映整体骨转换率,对诊断骨质疏松症及其分型、预测骨量丢失情况、评估完全骨折的危险性、监测药物治疗疗效等均有重要的意义。目前BALP、TRACP、PINP、β-CTX等骨转换标志物已被大量应用于临床,但每种骨转换标志物均有其特殊性及变异性,综合分析才能对骨质疏松的演变及治疗进展有一个较好的评判。本文主要探讨了临床常用的骨转换标志物的应用现状及应用前景。

Biochemical markers of bone metabolism are some bone matrix components generated from osteoblasts and osteoclasts and released into the blood and urine. They are used to reflect the overall rate of bone turnover, and have an important significance in the diagnosis of osteoporosis and classification, prediction of bone loss, assessment of complete fracture risk and monitoring drug efficacy, etc. At present, the bone turnover markers such as BALP, TRACP, PINP, β-CTX etc. have been applied in the clinic extensively. But each bone turnover marker has its particularity and variability. A comprehensive analysis is needed for a better judge of the evolution and treatment of osteoporosis. This article mainly explored the clinical application and perspective of commonly used bone turnover markers.

表1 骨形成标志物的正常参考值
表2 骨吸收标志物的正常参考值
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