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中华老年骨科与康复电子杂志 ›› 2025, Vol. 11 ›› Issue (03) : 186 -192. doi: 10.3877/cma.j.issn.2096-0263.2025.03.008

综述

维生素D受体基因与老年骨质疏松关系
王敬博1,(), 宋伟福2, 杨阳1, 张云鸽1, 李欣1   
  1. 1. 300211 天津市天津医院
    2. 537100 广西壮族自治区贵港市人民医院
  • 收稿日期:2023-01-27 出版日期:2025-06-05
  • 通信作者: 王敬博
  • 基金资助:
    天津市卫生健康委员会科技项目(ZC20222)

The relationship between Vitamin D receptor genes and osteoporosis in the age

Jingbo Wang1,(), Weifu Song, Yang Yang1, Yunge Zhang1, Xin Li1   

  1. 1. Tianjin Hospital of Tianjin,Tianjin 300211,China
  • Received:2023-01-27 Published:2025-06-05
  • Corresponding author: Jingbo Wang
引用本文:

王敬博, 宋伟福, 杨阳, 张云鸽, 李欣. 维生素D受体基因与老年骨质疏松关系[J/OL]. 中华老年骨科与康复电子杂志, 2025, 11(03): 186-192.

Jingbo Wang, Weifu Song, Yang Yang, Yunge Zhang, Xin Li. The relationship between Vitamin D receptor genes and osteoporosis in the age[J/OL]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2025, 11(03): 186-192.

维生素D受体(VDR)基因是目前涉及研究人体骨密度、骨质疏松症表现和发展的重要候选基因之一,其多态性影响着心血管、神经、内分泌系统等人体多个系统、器官疾患的发生,并与骨骼肌肉力量和骨质疏松骨折的发生相关,还影响着人体对补充维生素D和钙剂的反应。VDR基因多态性的表达受到钙摄入量和其它基因的调节,其作用受种族、性别和年龄的影响。

Vitamin D receptor (VDR) gene is one of the important candidate genes , currently involved in the study of human bone mineral density,osteoporosis performance and development,which polymorphism affects the occurrence of diseases at the human cardiovascular, nervous, endocrine or other systems, and relates to the skeletal muscle strength and the occurrence of osteoporotic fracture, also affects the reaction of the supplement of vitamin D and calcium on body health. The expression of polymorphisms in the VDR gene is regulated by the intake of calcium and vitamin D and other genes,and its effects are influenced by race,sex,and age.

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