Research progress of mesenchymal stem cells and their exosomes in the treatment of osteoarthritis

doi:10.3877/cma.j.issn.2096-0263.2019.02.010

Abstract

Abstract:

Osteoarthritis is the most common chronic degenerative bone and joint disease. Due to the limited self-healing ability of cartilage, the current treatment strategy cannot achieve a curative effect on osteoarthritis. Recently, accumulated evidences have shown that mesenchymal stem cells play critical roles in the OA treatment. Furthermore, it is known that the paracrine effects of mesenchymal stem cells have the role of anti-inflammation and immunomodulation under abnormal conditions, in which exosomes may play an important role. Exosomes are able to retard the progression of OA by regulating intercellular signal transduction, tissue damage repair, and immune regulation. Mesenchymal stem cells and their derived exosomes provide new therapeutic strategies for the treatment of OA. However, more and more large animal studies are needed to better determine the biological safety and therapeutic characteristics of mesenchymal stem cells and their derived exosomes for the treatment of osteoarthritis. This article focused on the role and mechanism of mesenchymal stem cells and their derived exosomes in osteoarthritis.

Key words: Mesenchymal stem cell, Exosomes, Osteoarthritis, Chondrocytes, External cell matrix

Hongbin Wu, Hua Yang, Jian Wang, Hong Sun. Research progress of mesenchymal stem cells and their exosomes in the treatment of osteoarthritis[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2019, 05(02): 114-117.

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