Progress of the role of EGFR signaling pathway in osteoarthritis

doi:10.3877/cma.j.issn.2096-0263.2019.02.009

Abstract

Abstract:

Chondrocytes form articular cartilage on the surface of arthrosis. The proliferation, differentiation, apoptosis and metabolic imbalance of articular chondrocytes will lead to the occurrence of osteoarthritis (OA). Recent studies have shown that EGFR signaling pathway is a multifunctional cytokine, which is closely related to the pathological and physiological processes of various organs and tissues, and plays an important role in regulating the growth and metabolism of chondrocytes. Therefore, this review focuses on the role and mechanism of EGFR signaling pathway in OA, in order to provide new methods and ideas for the research and treatment of OA and other bone and joint diseases.

Key words: Receptor, epidermal growth factor, Osteoarthritis, Chondrocytes, Biological functions

Wenbo Zeng, Shenghui Lan, Xianhua Cai, Ximing Liu. Progress of the role of EGFR signaling pathway in osteoarthritis[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2019, 05(02): 109-113.

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