| 1 |
Wang D, Shen J, Wang Y, et al. Mechanisms of Ferroptosis in bone disease: A new target for osteoporosis treatment [J]. Cell Signal, 2025, 127: 111598.
|
| 2 |
Wu X, Fang X, Lu F, et al. An update on the role of ferroptosis in the pathogenesis of osteoporosis [J]. EFORT Open Rev, 2024, 9(8): 712-22.
|
| 3 |
Zhang Y, Qu Z, Zhao Y, et al. The Therapeutic Effect of Natural Compounds on Osteoporosis through Ferroptosis [J]. Curr Med Chem, 2024, 31 (18): 2629-48.
|
| 4 |
Qu Z, Zhang B, Kong L, et al. Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 signaling pathway [J]. J Leukoc Biol, 2024, 115(5): 946-57.
|
| 5 |
Huang W, Hua F, Su T, et al. sEV-mediated lipid droplets transferred from bone marrow adipocytes promote ferroptosis and impair osteoblast function [J]. J Lipid Res, 2024, 65 (11): 100657.
|
| 6 |
Li Z, Li D, Chen R, et al. Cell death regulation:A new way for natural products to treat osteoporosis [J]. Pharmacol Res, 2023, 187: 106635.
|
| 7 |
Jiang Z, Wang H, Qi G, et al. Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study [J]. IUBMB Life, 2022, 74 (11): 1052-69.
|
| 8 |
Zhang H, Wang A, Li G, et al. Osteoporotic bone loss from excess iron accumulation is driven by NOX4-triggered ferroptosis in osteoblasts [J]. Free Radic Biol Med, 2023, 198: 123-36.
|
| 9 |
Zhang J, Zhang L, Yao G, et al. NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis [J]. Cell Biol Toxicol, 2023, 39(6): 3305-21.
|
| 10 |
Luo C, Xu W, Tang X, et al. Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation [J]. Free Radic Biol Med, 2022, 188: 337-50.
|
| 11 |
Zhang Y, Cong Y, Du J, et al. Lif-deficiency promote systemic Iron metabolism disorders and increases the susceptibility of osteoblasts to ferroptosis [J]. Bone, 2024, 189: 117266.
|
| 12 |
Huang Y, Zhang J, Zhu Y, et al. BMP9 alleviates iron accumulation-induced osteoporosis via the USP10/FOXO1/GPX4 axis [J]. J Adv Res, 2026, 79: 953-972.
|
| 13 |
杨帆，徐又佳.重视骨质疏松症患者铁代谢指标的评估[J].中华骨质疏松和骨矿盐疾病杂志, 2017, 10 (2): 99-103.
|
| 14 |
Long S W, Li S H, Li J, et al. Identification of osteoporosis ferroptosis-related markers and potential therapeutic compounds based on bioinformatics methods and molecular docking technology [J]. BMC Med Genomics, 2024, 17(1): 99.
|
| 15 |
林适，王世浩，刘树华，等.铁死亡血清学标志物在绝经后骨质疏松症发病中的作用及预测模型构建[J].中国骨质疏松杂志, 2023, 29(5): 625-30+81.
|
| 16 |
Zhu S, Chen W, Masson A, et al. Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis [J]. Cell Discov, 2024, 10(1): 71.
|
| 17 |
Suh J, Lee Y S, et al. The multifaceted roles of mitochondria in osteoblasts:from energy production to mitochondrial-derived vesicle secretion [J]. J Bone Miner Res, 2024, 39 (9): 1205-14.
|
| 18 |
Deng X, Lin B, Wang F, et al. Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway [J]. Phytomedicine, 2024, 124: 155282.
|
| 19 |
Ruan B, Dong J, Wei F, et al. DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis [J]. Bone Res, 2024, 12(1): 68.
|
| 20 |
Chen S, Xiao J, Zhou S, et al. The GPR30-Mediated BMP-6/HEP/FPN Signaling Pathway Inhibits Ferroptosis in Bone Marrow Mesenchymal Stem Cells to Alleviate Osteoporosis [J]. Int J Mol Sci, 2025, 26(5): 2027.
|
| 21 |
Hao J, Bei J, Li Z, et al. Qing'e Pill Inhibits Osteoblast Ferroptosis via ATM Serine/Threonine Kinase (ATM) and the PI3K/AKT Pathway in Primary Osteoporosis [J]. Front Pharmacol, 2022, 13: 902102.
|
| 22 |
Tao L, Wang J, Wang K, et al. Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1 [J]. Aging Cell, 2024, 23(8): e14181.
|
| 23 |
Zhu Q, Chen Z, Fu T, et al. ZC3H13 Regulates Ferroptosis to Enhance Osteogenic Differentiation in Osteoporotic BMSCs [J]. Tissue Eng Part A, 2025, 31(19-20): 1171-1185.
|
| 24 |
Elson A, Anuj A, Barnea-Zohar M, et al. The origins and formation of bone-resorbing osteoclasts [J]. Bone, 2022, 164: 116538.
|
| 25 |
Jin Y, Wu S, Zhang L, et al. Artesunate inhibits osteoclast differentiation by inducing ferroptosis and prevents iron overload-induced bone loss [J]. Basic Clin Pharmacol Toxicol, 2023, 132(2): 144-53.
|
| 26 |
Xue C, Luo H, Wang L, et al. Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-κB signaling [J]. Front Endocrinol (Lausanne), 2023, 14: 1234563.
|
| 27 |
Lan C, Zhou X, Shen X, et al. Suppression of IRF9 Promotes Osteoclast Differentiation by Decreased Ferroptosis via STAT3 Activation [J]. Inflammation, 2024, 47(1): 99-113.
|
| 28 |
Ni S, Yuan Y, Qian Z, et al. Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis [J]. Free Radic Biol Med, 2021, 169: 271-82.
|
| 29 |
Piñera-Avellaneda D, Buxadera-Palomero J, Ginebra M P, et al. Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation [J]. Front Bioeng Biotechnol, 2023, 11: 1303313.
|
| 30 |
Chen H, Han Z, Wang Y, et al. Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives [J]. J Inflamm Res, 2023, 16: 4661-77.
|
| 31 |
Li Y, Li Y, Li P, et al. 4-Octyl Itaconate Attenuates Postmenopausal Osteoporosis by Inhibiting Ferroptosis and Enhancing Osteogenesis via the Nrf2 Pathway [J]. Inflammation, 2025, 48(5): 3326-3339.
|
| 32 |
Hu X, Wang Z, Wang W, et al. Irisin as an agent for protecting against osteoporosis:A review of the current mechanisms and pathways [J]. J Adv Res, 2024, 62: 175-86.
|
| 33 |
Föger-Samwald U, Kerschan-Schindl K, Butylina M, et al. Age Related Osteoporosis: Targeting Cellular Senescence [J]. Int J Mol Sci, 2022, 23(5): 2701.
|
| 34 |
Liu T, Wang Y, Qian B, et al. Potential Metabolic Pathways Involved in Osteoporosis and Evaluation of Fracture Risk in Individuals with Diabetes [J]. Biomed Res Int, 2024, 2024: 6640796.
|
| 35 |
Yan C, Zhang J, An F, et al. Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis [J]. Front Public Health, 2022, 10: 910675.
|
| 36 |
Huang C, Li Y, Li B, et al. Identifying potential ferroptosis key genes for diagnosis and treatment of postmenopausal osteoporosis through competitive endogenous RNA network analysis [J]. Heliyon, 2024, 10 (1): e23672.
|
| 37 |
Weinberg ED. Iron loading: a risk factor for osteoporosis [J]. Biometals, 2006, 19(6): 633-5.
|
| 38 |
Yang Y, Zhang X, Yang Y, et al. A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant [J]. Bioact Mater, 2024, 41: 336-54.
|
| 39 |
Zhang QY, Gong HB, Jiang MY, et al. Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis [J]. Nat Commun, 2025, 16(1): 758.
|
| 40 |
Jiang Z, Qi G, He X, et al. Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis [J]. Adv Sci (Weinh), 2024, 11 (12): e2307388.
|
| 41 |
Li P, Wang Y, Yan Q, et al. Fructus Ligustri Lucidi inhibits ferroptosis in ovariectomy-induced osteoporosis in rats via the Nrf2/HO-1 signaling pathway [J]. Biomed Rep, 2024, 20(2): 27.
|
| 42 |
Deng X, Xiao W, Lin B, et al. Synergistic anti-osteoporosis effects of Anemarrhena asphodeloides bunge-Phellodendron chinense C.K. Schneid herb pair via ferroptosis suppression in ovariectomized mice [J]. Front Pharmacol, 2024, 15: 1378634.
|
| 43 |
Zheng Y, Tan X, Wang X, et al. Targeting ferroptosis with natural products in stroke:therapeutic mechanisms and translational opportunities [J]. Front Pharmacol, 2025, 16: 1586345.
|
| 44 |
Zheng X, Ye F C, Sun T, et al. Delay the progression of glucocorticoid-induced osteoporosis:Fraxin targets ferroptosis via the Nrf2/GPX4 pathway [J]. Phytother Res, 2024, 38(11): 5203-24.
|
| 45 |
Li M, Yang N, Hao L, et al. Melatonin Inhibits the Ferroptosis Pathway in Rat Bone Marrow Mesenchymal Stem Cells by Activating the PI3K/AKT/mTOR Signaling Axis to Attenuate Steroid-Induced Osteoporosis [J]. Oxid Med Cell Longev, 2022, 2022: 8223737.
|
| 46 |
Yang RZ, Xu WN, Zheng HL, et al. Exosomes derived from vascular endothelial cells antagonize glucocorticoid-induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts [J]. J Cell Physiol, 2021, 236(9): 6691-705.
|
| 47 |
Lu J, Yang J, Zheng Y, et al. Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence [J]. Sci Rep, 2019, 9(1): 16130.
|
| 48 |
Li Y, Cai Z, Ma W, et al. A DNA tetrahedron-based ferroptosis-suppressing nanoparticle:superior delivery of curcumin and alleviation of diabetic osteoporosis [J]. Bone Res, 2024, 12(1): 14.
|
| 49 |
Wang M, Liu Y, Gui H, et al. ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway [J]. Eur J Pharmacol, 2024, 969: 176303.
|
| 50 |
Ma HD, Shi L, Li HT, et al. Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis [J]. World J Diabetes, 2024, 15 (5): 977-87.
|
| 51 |
Lin Y, Shen X, Ke Y, et al. Activation of osteoblast ferroptosis via the METTL3/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss [J]. Faseb J, 2022, 36(3): e22147.
|
| 52 |
Xu C Y, Xu C, Xu Y N, et al. Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway [J]. Phytomedicine, 2024, 125: 155342.
|
| 53 |
Wei F, Ruan B, Dong J, et al. Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis [J]. J Adv Res, 2024, 75: 331-344.
|
| 54 |
Jin C, Tan K, Yao Z, et al. A Novel Anti-Osteoporosis Mechanism of VK2:Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis [J]. J Agric Food Chem, 2023, 71(6): 2745-61.
|
| 55 |
Zhang Z, Ji C, Wang Y N, et al. Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis [J]. Cells, 2022, 11(16): 2560.
|
| 56 |
Yang Y, Lin Y, Wang M, et al. Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis [J]. Bone Res, 2022, 10(1): 26.
|
| 57 |
Wei X, Jiang Y, Chenwu F, et al. Synergistic Ferroptosis-Immunotherapy Nanoplatforms: Multidimensional Engineering for Tumor Microenvironment Remodeling and Therapeutic Optimization [J]. Nano-Micro Letters, 2025, 18 (1): 56.
|
| 58 |
Wang Y, Sun L, Dong Z, et al. Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis [J]. Mater Today Bio, 2025, 31: 101501.
|
| 59 |
Jing Z, Li Y, Zhang H, et al. Tobacco toxins induce osteoporosis through ferroptosis [J]. Redox Biol, 2023, 67: 102922.
|
| 60 |
Xu P, Lin B, Deng X, et al. VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis [J]. Free Radic Biol Med, 2022, 193(Pt 2): 720-35.
|
| 61 |
Yin Y, Chen G J, Yang C, et al. Osteocyte ferroptosis induced by ATF3/TFR1 contributes to cortical bone loss during ageing [J]. Cell Prolif, 2024, 57 (10): e13657.
|
| 62 |
梁松林,成文翔,张鹏,等.成骨细胞程序性死亡的研究进展[J].中国骨质疏松杂志, 2024, 30(3): 385-90.
|
| 63 |
Yang H, Ru K, Liu S, et al. Targeting Ferroptosis: Emerging Insights into Osteoporosis Mechanisms [J]. Biology, 2025, 14(8): 1062.
|
| 64 |
Yang D, Gong G, Song J, et al. Ferroptosis-mediated osteoclast-osteoblast crosstalk:signaling pathways governing bone remodeling in osteoporosis [J]. J Orthop Surg Res, 2025, 20 (1): 888.
|
| 65 |
Zhou H, Deng J, Chen J, et al. Cellular mechanisms of osteoporosis: A comprehensive perspective on ferroptosis, cuproptosis and lipid metabolism abnormalities [J]. BMT, 2025, 2025, 7(1): 1-17.
|
| 66 |
Yu Q, Xiao Y, Guan M, et al. Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes [J]. Front Mol Biosci, 2024, 11: 1472492.
|
| 67 |
Chen S Y, Chen W, Gao Z, et al. Cuproptosis and Diabetic Osteoporosis:Mechanisms and Therapeutic Prospects [J]. Int J Mol Sci, 2026, 27(3): 1307.
|
| 68 |
Hu H T, Zhang Z Y, Luo Z X, et al. Emerging regulated cell death mechanisms in bone remodeling:decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders [J]. Cell Death Discovery, 2025, 11(1): 335.
|