切换至 "中华医学电子期刊资源库"

中华老年骨科与康复电子杂志 ›› 2019, Vol. 05 ›› Issue (05) : 297 -300. doi: 10.3877/cma.j.issn.2096-0263.2019.05.010

所属专题: 文献

综述

骨质疏松症治疗药物的分类与用药选择
王建华1,()   
  1. 1. 300457 天津市泰达医院骨二科
  • 收稿日期:2019-06-10 出版日期:2019-10-05
  • 通信作者: 王建华
  • 基金资助:
    国家自然科学基金(30772193)

Classification and selection of drugs for treating osteoporosis

Jianhua Wang1,()   

  1. 1. Department of Orthopedic, Tianjin TEDA Hospital, Tianjin 300457, China
  • Received:2019-06-10 Published:2019-10-05
  • Corresponding author: Jianhua Wang
引用本文:

王建华. 骨质疏松症治疗药物的分类与用药选择[J]. 中华老年骨科与康复电子杂志, 2019, 05(05): 297-300.

Jianhua Wang. Classification and selection of drugs for treating osteoporosis[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2019, 05(05): 297-300.

骨质疏松症是影响老年骨骼健康的主要疾病,其致残率和致死率高,严重影响着患者的生活质量和寿命,并给家庭和社会带来巨大人力和经济负担。随着人口老龄化进程的加剧,骨质疏松症越来越为社会所关注,抗骨质疏松药物研究已成为热点。传统的分类方法是按药物作用机制进行分类,种类繁多的药物使临床用药选择困难。治疗过程中应该既要考虑药物作用机制又要考虑患者个体机能,本着方便选择用药的原则进行了重新分类。

Osteoporosis is the main disease affecting the health of the elderly. Its disability and mortality are high, which seriously affects the quality of life and life of patients, and brings huge human and economic burden to families and society. With the intensification of the population aging process, osteoporosis has become more and more concerned by the society, and anti-osteoporosis drug research has become a hot spot. Traditional classification methods are classified according to the mechanism of action of drugs, and a wide variety of drugs make clinical drug selection difficult. In the course of treatment, both the mechanism of action of the drug and the individual function of the patient should be considered, and the principle of drug selection should be reclassified.

[1]
中国健康促进基金会骨质疏松防治中国白皮书编委会.骨质疏松症中国白皮书[J].中华健康管理学杂志, 2009, 3(3): 148-154.
[2]
Cosman F,De Beur SJ,Leboff MS, et al. Clinician's guide to prevention and treatment of osteoporosis [J]. Osteoporos Int, 2014, 25(10): 2359-2381.
[3]
Rivadeneira F,Mäkitie O. Osteoporosis and bone mass disorders:from genepathwaystotreatments [J]. Trends Endocrinol Metab, 2016, 27(5): 262-281.
[4]
Seeman E,Delmas PD. Bone quality-thematerial and structural basis of bone strength and fragility [J]. N Engl J Med, 2008, 26(1): 1-8.
[5]
Mafi Golchin M,Heidari L,Ghaderian SM, et al. Osteoporosis: a silent disease with complex genetic contribution [J]. J Genetics Genomics, 2016, 43(2): 49-61.
[6]
Lewiecki EM. New targetsforintervention in the treatment of postmenopausal osteoporosis [J]. Nat Rev Rheumatol, 2011, 7(11): 631-638.
[7]
Balk EM,Adam GP,Langberg VN, et al. International osteoporosis foundation Calcium steering committee [J]. Global dietary calcium intake among adults:a systematic review[J].Osteoporos Int, 2017, 28(12): 3315-3324.
[8]
NordinBE. Calcium and osteoporosis [J]. Nutrition, 1997, 13(7/8): 664-686.
[9]
Wu J,Xu L,Lv Y, et al. Quantitative analysis of efficacy and associated factors of calcium intake on bone mineral density in postmenopausal women [J]. Osteoporos Int, 2017, 28(6): 2003-2010.
[10]
中华医学会骨质疏松和骨矿盐疾病学会.原发性骨质疏松症诊疗指南(2017) [J].中华骨质疏松和骨矿盐疾病杂志, 2017, 10(5): 413-444.
[11]
Dawson-Hughes B. What is the optimal dietary intake of vitamin D for reducing fracture risk? [J]. Calcif Tissue Int, 2013, 92(2):184-190.
[12]
Wahl DA,CooperC,EbelingPR, etal. A global representation of vitamin D status in healthy populations[J]. Arch Osteoporos, 2012, 7:155-172.
[13]
Li M,Lv F,Zhang Z, et al. Establishment of a normal reference value of parathyroid hormone in a large healthy Chinese population and evaluation of its relation to bone turnover and bone mineral density [J]. OsteoporosInt, 2016, 27(5): 1907-1916.
[14]
Holick MF. Vitamin D deficiency [J]. N Engl J Med, 2007, 357(3): 266-281.
[15]
Han SL,Wan SL. Effect of teriparatide on bone mineral density and fracture in postmenopausal osteoporosis: meta-analysis of randomised controlled trials [J]. Int J Clin Pract, 2012, 66(2): 199-209.
[16]
Carmel AS,Shieh A,Bang H, et al. The 25(OH)D level needed to maintain a favorable bisphosphonate response is≥33 ng/ml [J]. Osteoporos Int, 2012, 23(10): 2479-2487.
[17]
Peris P,Martínez-Ferrer A,Monegal A, et al.25 hydroxyvitamin D serum levels influence adequate response to bisphosphonate treatment in postmenopausal osteoporosis[J].Bone, 2012, 51(1): 54-58.
[18]
陈志军,邱勇.雌激素对骨骼作用机制的研究进展[J].中华创伤杂志, 2008, 24(4): 314-317.
[19]
WeitzmannMN,PacificiR. Estrogen deficiency and bone loss:aninflammatorytale [J]. JClinInvest, 2006, 116(5): 118.
[20]
易剑华,蒋志平.骨质疏松症的药物治疗进展[J].现代医院,2006,6(11): 55-56.
[21]
林华,包丽华,韩祖斌,等.降钙素治疗骨质疏松症骨质量病变的研究[J].中华骨科杂志, 2001, 21(9): 6-8.
[22]
李晓林,罗新乐,余楠生,等.鲑鱼降钙素对骨质疏松大鼠骨折愈合的影响[J].中国骨质疏松杂志, 2003, 9(2): 17-19, 53.
[23]
Lj X,Luo X,Yu N, et al. Effects of salmon calcitonin onfracture healing in ovariectomizedrats [J]. Saudi Med J, 2007, 28(1): 60-64.
[24]
Canalis E,Giustina A,Bilezikian JP. Mechanisms of anabolic therapies for osteoporosis [J]. N Engl J Med, 2007, 357(9): 905-916.
[25]
Bukata SV,Puzas JE. Orthopedic uses of teriparatide [J]. CurrOsteoporos Rep, 2010, 8(1): 28-33.
[26]
NakajimaA,ShimojiN,ShiomiK,et a1.Mechanisms for theenhancement of fracture healing in ratstreated with intermittentlow-dosehumanparathyroidhormone(1-34)[J].JBone MinerRes,2002,17(11):2038-2047.
[27]
Taranta A,Brama M,Teti A, et al. The selective estrogenreceptormodulatorraloxifeneregulates osteoclast and osteoblast activity in vitro [J]. Bone, 2002, 30(2): 368-376.
[28]
刘立朝,樊继援.雷洛昔芬对去卵巢大鼠骨组织雌激素受体α表达水平的调节[J].中华骨质疏松和骨矿盐疾病杂志, 2013, 6(2): 161-164.
[29]
廖晖,李锋.二磷酸盐抑制骨吸收作用机制的研究现状[J].生物骨科材料与临床研究, 2004, 1(2): 20-24.
[30]
Abe Y,Iba K,Sasaki K, et al. Inhibitory effect of bisphosphonate on osteoclast function contributes to improved skeletal pain in ovariectomized mice [J]. J Bone Miner Metab, 2015, 33(2): 125-134.
[31]
FleischH.Canbisphosphonates be given to patients with fractures? [J].JBoneMinerRes, 2001, 16(3): 437-440.
[32]
Schilcher J,Koeppen V,Aspenberg P, et al. Risk of atypical femoral fracture during and after bisphosphonate use [J]. N Engl J Med, 2014, 371(10): 974-976.
[33]
Moen MD,Keam SJ. Denosumab: areview of itsuse in thetreatment of postmenopausalosteoporosis[J].DrugsAging, 2011, 28(1): 63-82.
[34]
Mcclung MR,Boonen ST,Rring O, et al. Effect of denosumab treatment on the risk of fractures in subgroups of women with postmenopausal osteoporosis[J]. Journal of bone and mineral research,2012, 27(1):211-218.
[35]
Nikhil K,Sharan S,Roy P. A pterostilbene derivative suppresses osteoclastogenesis by regulating RANKL-mediated NFκB and MAPK signaling in RAW264.7 cells[J]. Pharmacological Reports, 2015, 67(6):1264-1272.
[36]
Ke HZ,Richards WG,Li XD, et al. Sclerostin and dickkopf-1 as therapeutic targets in bone diseases [J]. Endocr Rev, 2012, 33(5): 747-783.
[1] 段燕, 郭欣, 吕慧芳, 王国利, 黄明光, 董英俊. 乳腺癌患者辅助化疗后感染肺孢子菌一例[J]. 中华乳腺病杂志(电子版), 2023, 17(05): 318-321.
[2] 中华医学会骨科学分会关节外科学组, 广东省医学会骨质疏松和骨矿盐疾病分会, 广东省佛山市顺德区第三人民医院. 中国髋部脆性骨折术后抗骨质疏松药物临床干预指南(2023年版)[J]. 中华关节外科杂志(电子版), 2023, 17(06): 751-764.
[3] 杨霁, 黄顺梅, 王安鸽, 吴月, 杨云梅. 杭州地区老年人群中肌少症患病情况及其与骨质疏松症的相关性分析[J]. 中华危重症医学杂志(电子版), 2023, 16(03): 207-210.
[4] 江泽莹, 王安婷, 王姣丽, 陈慈, 周秋玲, 黄燕娟, 周芳, 薛琰, 周剑烽, 谭文勇, 杜美芳. 多种植物油组分预防肿瘤放化疗相关毒性反应的效果分析[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 523-527.
[5] 陆宜仙, 张震涛, 夏德萌, 王家林. 巨噬细胞极化在骨质疏松中调控作用及机制的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 538-541.
[6] 陈跃圻, 罗睿, 向涵, 余泳妍, 余挺. 骨质疏松症与牙周炎的因果关系:一项两样本孟德尔随机化研究[J]. 中华口腔医学研究杂志(电子版), 2023, 17(04): 292-298.
[7] 汪必涛, 王征, 王国斌. 林奇综合征的治疗现状及进展[J]. 中华普外科手术学杂志(电子版), 2023, 17(03): 332-335.
[8] 南方护骨联盟前列腺癌骨转移专家组. 前列腺癌骨转移诊疗专家共识(2023版)[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(03): 201-208.
[9] 刘德海, 刘一昀, 蓝倩倩, 孙彤, 边林博, 秦锐, 邱磊, 周一凡, 齐虹. 老视药物疗法的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(03): 177-182.
[10] 张茜, 刘叶青, 康雪莹, 孙兵兵, 刘岩, 胡丽叶, 周亚茹. 血清铁蛋白与绝经后骨质疏松症的相关性分析[J]. 中华老年骨科与康复电子杂志, 2023, 09(03): 166-171.
[11] 周加军, 余永武, 周涵, 刘勇, 张凌. 甲状旁腺切除对继发性甲状旁腺功能亢进患者骨密度及骨代谢的影响[J]. 中华临床医师杂志(电子版), 2023, 17(06): 706-710.
[12] 戴俊, 李硕, 曹影, 汪守峰, 宋红毛, 蔡菁菁, 邵敏, 陈莉, 程雷, 怀德. 鼻内镜下改良高选择性翼管神经低温等离子消融术对中重度变应性鼻炎的效果研究[J]. 中华临床医师杂志(电子版), 2023, 17(06): 689-693.
[13] 田明达, 吴珺, 王会娟, 张欣, 沙玉英, 陈琳, 赵宾洋. 6297名0~3岁婴幼儿超声骨密度检测结果分析[J]. 中华临床医师杂志(电子版), 2023, 17(06): 644-647.
[14] 白晓辉, 张龙, 王永峰, 冯毅, 赵斌, 吕智, 徐朝健. 单侧与双侧经皮椎体成形术治疗Kummell病的疗效比较[J]. 中华老年病研究电子杂志, 2023, 10(02): 14-18.
[15] 戚晓阳, 杨平, 杜忠秋, 邱旭升, 汤黎明, 陈一心. 袖状胃切除术对肥胖合并2型糖尿病大鼠模型骨密度的影响[J]. 中华肥胖与代谢病电子杂志, 2023, 09(02): 102-108.
阅读次数
全文


摘要