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中华老年骨科与康复电子杂志

中华老年骨科与康复电子杂志 ›› 2019, Vol. 05 ›› Issue (02) : 114 -117. doi: 10.3877/cma.j.issn.2096-0263.2019.02.010

所属专题： 文献；

综述

间充质干细胞及其来源的外泌体在骨关节炎治疗中的研究进展
吴鸿斌1, 杨华2, 汪健2, 孙红2,†()   
  1. 1. 550004　贵阳，贵州医科大学附属医院骨科；550004　贵阳，贵州医科大学
    2. 550004　贵阳，贵州医科大学附属医院骨科
  • 收稿日期:2018-05-18 出版日期:2019-04-05
  • 通信作者: 孙红
  • 基金资助:
    贵州省科技计划项目(黔科合LH字[2016]7253号)

Research progress of mesenchymal stem cells and their exosomes in the treatment of osteoarthritis

Hongbin Wu1, Hua Yang2, Jian Wang2, Hong Sun2,†()   

  1. 1. Department of Orthopedics, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China; Guizhou Medical University, Guiyang 550004, China
  • Received:2018-05-18 Published:2019-04-05
  • Corresponding author: Hong Sun
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吴鸿斌, 杨华, 汪健, 孙红. 间充质干细胞及其来源的外泌体在骨关节炎治疗中的研究进展[J]. 中华老年骨科与康复电子杂志, 2019, 05(02): 114-117.

Hongbin Wu, Hua Yang, Jian Wang, Hong Sun. Research progress of mesenchymal stem cells and their exosomes in the treatment of osteoarthritis[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2019, 05(02): 114-117.

骨关节炎（OA）是最常见的慢性退行性骨关节疾病，由于软骨的自愈能力有限，目前的治疗策略对OA无法达到治愈效果。近年来，越来越多的证据表明间充质干细胞治疗OA可获得较好的疗效。深入研究表明，间充质干细胞的旁分泌机制可在机体异常条件下发挥抗炎、免疫调节作用，而外泌体可能在此机制中扮演着重要的角色。外泌体可通过调控细胞间信号转导、损伤组织修复及免疫调节等过程，从而延缓OA进程。间充质干细胞及其来源的外泌体为治疗OA提供了新的治疗策略，但仍需更大量及大型动物研究以更好的验证间充质干细胞及其来源的外泌体用于治疗OA的生物安全性和治疗特征。本文就间充质干细胞及其来源的外泌体在OA中的作用及机制作一综述。

关键词: 间充质干细胞, 外泌体, 骨性关节炎, 软骨细胞, 细胞外基质

Osteoarthritis is the most common chronic degenerative bone and joint disease. Due to the limited self-healing ability of cartilage, the current treatment strategy cannot achieve a curative effect on osteoarthritis. Recently, accumulated evidences have shown that mesenchymal stem cells play critical roles in the OA treatment. Furthermore, it is known that the paracrine effects of mesenchymal stem cells have the role of anti-inflammation and immunomodulation under abnormal conditions, in which exosomes may play an important role. Exosomes are able to retard the progression of OA by regulating intercellular signal transduction, tissue damage repair, and immune regulation. Mesenchymal stem cells and their derived exosomes provide new therapeutic strategies for the treatment of OA. However, more and more large animal studies are needed to better determine the biological safety and therapeutic characteristics of mesenchymal stem cells and their derived exosomes for the treatment of osteoarthritis. This article focused on the role and mechanism of mesenchymal stem cells and their derived exosomes in osteoarthritis.

Key words: Mesenchymal stem cell, Exosomes, Osteoarthritis, Chondrocytes, External cell matrix
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