Bisphosphonates and atypical femur fractures femur

doi:10.3877/cma.j.issn.2096-0263.2018.02.010

Abstract

Abstract:

Osteoporosis is a condition associated with significant morbidity and mortality, resulting increased risk of fractures. Bisphosphonates have been shown to reduce the risk of osteoporotic fracture in numerous large clinical trials, particularly alendronate sodium have been extensively and successfully used for the treatment of osteoporosis. As a result of inhibition of bone resorption (through the inhibition of osteoclasts activity), bisphosphonates may cause accumulation of trabecular microdamage or perhaps contribute to the aging of collagen fibers. Long-term use of bisphosphonates causes an increased risk of atypical femoral fractures (AFF). Six broad themes related to the pathogenesis and management of bisphosphonate-related AFFs are presented in this article and including mechanism of bisphosphonates action, pathogenesis of bisphosphonate-related AFF, risk factors for AFF, preventing bisphosphonate-related AFF, surgical management of bisphosphonate-related AFF and medical management of bisphosphonaterelated AFF.

Key words: Osteoporosis, Bisphosphonates, Femur fractures

Hao Xing, Qiang Liu, Dou Wu, Zhengwu Gao, Wei Liang, Yazhen Su, Yahui Geng. Bisphosphonates and atypical femur fractures femur[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2018, 04(02): 118-124.

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