Abstract:

Objective

To compare the diagnostic value of quantitative CT and dual-energy X-ray absorptiometry for osteoporosis.

Methods

PubMed， FEBM， The Cochrane Library， CBM， CNKI， Wanfang Database，VIP and other databases were searched from the establishment of the database to February 2022 to include relatedstudieson the diagnosis of osteoporosis by quantitative CT and（or）dual-energy X-ray absorptiometry， collect literature that can construct a 2x2 contingency table.The literatures were screened according to the inclusion and exclusion criteria of diagnostic tests，and the quality and risk of bias of the included literature were evaluated by QUADAS-2 literature quality assessment tool and ReviewManager 5.4 software，and Meta-analysis was performed by Stata 14.0 software.

Results

Twenty-one articles were finally included.The meta-analysis showed that the combined sensitivity （Sen combined） of quantitative CT in the diagnosis of osteoporosis was0.94 ［95% CI: 0.84， 0.98］， and the specificity （Spe combined） was 0.55 ［95% CI: 0.31，0.77］，the positive likelihood ratio（+LR combined）was 2.1［95%CI:1.2，3.8］，and the negative likelihood ratio （-LR combined） was 0.11 （95% CI: 0.03， 0.41）； dual energy The combined sensitivity （Sen combined） of X-rays for the diagnosis of osteoporosis was 0.70 ［95% CI: 0.36， 0.91］， the specificity （Spe combined） was 0.86［95%CI:0.55，0.97］，and the positive likelihood ratio（+LR pooled）was 5.1［95%CI:1.2，20.9］，negative likelihood ratio （-LR pooled） was 0.34 （95% CI: 0.12， 0.95）， and the respective diagnostic odds ratios（DOR pooled）were 18（95%CI:3，110）and 15（95%CI:2，115）；the areas under the SROC curve were 0.89［95%CI:0.85，0.91］and 0.86［95%CI:0.83，0.89］，respectively.

Conclusion

Both quantitative CT and dual-energy X-ray have high application value in the diagnosis of osteoporosis，and quantitative CT with higher diagnostic efficiency can be preferred in routine examination.

Key words: Quantitative CT, Dual Energy X-ray, Osteoporosis, Comparison, Meta-analysis