To explore the relationship between fracture risk assessment tool (FRAX), Asian osteoporosis self-screening tool (OSTA) and bone metabolism indexes including serum osteocalcin, 25-hydroxyvitamin D, β-crosslaps and procollagen type 1 N-terminal propeptide in the diagnosis of postmenopausal type 2 diabetes induced osteoporosis.

231 postmenopausal patients with Type 2 diabetes who were hospitalized in the Department of Endocrinology, the Affiliated Hospital of Nantong University from June 2020 to December 2021 were retrospectively analyzed. According to the results of bone mineral density, the patients were divided into normal bone mass group, osteopenia group and osteoporosis group. Based on the baseline data, the accuracy of FRAX, OSTA and bone metabolism indexes on the risk of osteoporosis in postmenopausal patients with Type 2 diabetes were evaluated respectively.

The FRAX score with bone mineral density in osteoporosis group was significantly higher than that in normal bone mass group and osteopenia group, and 25-hydroxyvitamin D level was significantly lower than that in normal bone mass group, the levels of β- CTX and P1NP were significantly higher than those in normal bone mass group (P<0.05); Pearson correlation analysis showed that bone mineral density has significant correlation with 25 hydroxyvitamin D, β- CTX and PINP (r=0.30, -0.45, -0.31, P<0.05); Receiver operator characteristic curve (ROC) analysis showed that: FRAX score with bone mineral density(Including the probability of major parts and hip fractures in the next 10 years), 25 hydroxyvitamin D, and β- CTX has diagnostic value in differentiating whether bone mass is normal or not (AUC=0.6935, 0.8462, 0.7118, 0.7484). And there was no significant difference in OSTA score between the groups.

FRAX and bone metabolism can assist in the diagnosis of postmenopausal Type 2 diabetes complicated with osteoporosis, which has potential clinical value for early diagnosis.