To investigate the relationship between the estrogen receptor alpha (ERα) rs2234639 polymorphism and osteoporosis in postmenopausal women.

CNKI, Wanfang, China WeiPu Library, PubMed, Google Scholar and EMBASE were searched, the search time limit is from the establishment of the database to October 2020, randomized controlled studies were collected on the association between polymorphism of estrogen receptor gene rs2234639 and osteoporosis in postmenopausal women. The NOS literature quality evaluation standard was used to evaluate the quality of the literature meeting the inclusion and exclusion criteria, and the OR value and its 95% confidence interval (95% CI) were used to evaluate the strength of the association. According to the heterogeneity, the fixed or random effect models were used to calculate the combined effects, and forest diagrams and funnel diagrams were drawn for meta-analysis.

The study finally included 10 articles that met the standards, including 1, 364 cases and 1, 482 controls, with a total sample of 2, 846 cases. The pooled OR was 0.605 and 95% CI was (0.326, 1.123) in the allele model of Asian population. No association between rs2234639 polymorphism and postmenopausal osteoporosis was found. The results of dominant model, recessive model and co dominant model were the same. The allele model and co dominant model (PP: pp) of Caucasian population showed that they were associated, but the dominant model, recessive model and co dominant model (Pp:pp) did not. No publication bias was found in this study (all P>0.05).

There is no significant association between the rs2234639 polymorphism of ERα gene and osteoporosis in postmenopausal women in Asian population. But the P allele is associated with a reduced risk of osteoporosis in postmenopausal women in the Caucasian population.