To systematically evaluate the relationship between calcitonin receptor gene polymorphism and osteoporosis.

The databases of CNKI, WanFang, CBM, PubMed and Embase were searched by computer to collect the literatures on the correlation between CTR gene polymorphism and osteoporosis, and the retrieval time was from October 2020. Two researchers independently screened the literature according to the inclusion and exclusion criteria and extracted the data. Stata11.0 software was used for statistical analysis, and the OR value and 95%CI were calculated. Subgroup analysis by ethnicity was performed for each included study, followed by sensitivity analysis and publication bias assessment.

A total of 14 case-control studies (4059 cases in total) were included and meta-analysis was performed on allelic, dominant, superdominant and heterozygous models. The results showed that both the allele model (T vs. C: OR=1.564, 95% CI: 1.013, 2.417, P=0.044) and the dominant gene model (TT+CT vs. CC: OR=2.436, 95% CI: 1.351, 4.389, P=0.003) and heterozygote gene model (CT vs. CC: OR=2.299, 95% CI: 1.450, 3.644, P=0.000), the polymorphism of CTR rs1801197 gene was significantly correlated with the risk of osteoporosis in Caucasian patients. Among the four gene models, there was no statistical correlation between the polymorphism of CTR rs1801197 gene and osteoporosis in Asians (P>0.05). No significant interstudy publication bias was found.

Results showed that allele model (T vs. C), dominant model (TT+CT vs. CC) and heterozygote model (CT vs. TT) of CTR rs1801197 were associated with the risk of osteoporosis in Caucasians.