Micro-RNA and autophagy regulation

doi:10.3877/cma.j.issn.2096-0263.2018.01.013

Abstract

Abstract:

Autophagy is a highly conserved cellular self-digestion and catabolism process in which proteins, damaged organelles in the cytoplasm were delivered to the lysosome for degradation. The dysregulation of autophagy can induce many pathological disorders, including neurodegenerative diseases, heart diseases, cancer, bone metabolic diseases and senility. It’s under precise control. MicroRNA is a classic functional small RNA molecules that regulate target genes at a post-transcriptional level. More and more studies indicated that microRNAs are involved in the regulation of autophagy-related genes and other regulatory factors. It is also a potential target in treating disregulated autophagy diseases by changing the level of autophagy through related genes and factors regulation. This review aims to summarize the latest reports on microRNA and autophagy regulation.

Key words: Autophagy, MicroRNAs, RNA interference, Disease

Bo Liu, Zhongbin Chen, Lihai Zhang, Peifu Tang. Micro-RNA and autophagy regulation[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2018, 04(01): 57-61.

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