Treatment with lenalidomide and dexamethasone for elderly multiple myeloma

doi:10.3877/cma.j.issn.2096-0263.2018.01.005

Abstract

Abstract:

Objective

To evaluate the efficacy and safety of lenalidomide plus low-dose dexamethasone in the treatment of elderly multiple myeloma (MM) patients.

Methods

The clinical records of 36 elderly MM patients were analyzed including 23 males (63.9%) and 13 females (36.1%). The average age was 72.0±2.4 years and all patients were treated with lenalidomide plus low-dose dexamethasone (lenalidomide 25 mg/qod or 10 mg/qd on day 1-21 of each 28-day cycle, dexamethasone 10-20 mg per week). Adverse reaction and therapeutic efficacy was determined by NCICTCAE (3^rd edition) and IMWG.

Results

There were 36 patients well followed-up with an average of 20±3 months, range of 1-48 months, the complete ratio of follow-up was 100%, 1 patient (2.7%) achieved complete response (CR), 10 cases (27.8%) were very good partial response (VGPR), 13 cases (36.1%) were partial response (PR), 6 cases (16.7%) were stable disease (SD), 4 cases (11.1%) were progressive and 2 died (5.6%). The overall response rate (ORR=CR+VGPR+PR) was 24/36 (66.6%). The most common adverse was fatigue and dexamyelosuppression.

Conclusion

Lenalidomide plus low-dose dexamethasone is a safe and effective treatment for elderly MM patients. This combined treatment is recommended to elderly MM patients.

Key words: Lenalidomide, Aged, Multiple myeloma

Ran Tang, Yuping Zhong, Jiajia Zhang, Xin Li, Na An, Man Shen. Treatment with lenalidomide and dexamethasone for elderly multiple myeloma[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2018, 04(01): 20-22.

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References 15

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项目		?
年龄（岁，±s）		72.0±2.4
性别[例（%）]		?
?	男	23（63.9）
?	女	13（36.1）
重链类型[例（%）]		?
?	IgG	16（44.3）
?	IgA	12（33.3）
?	IgD	2（5.6）
轻链类型[例（%）]		?
?	κ轻链	2（5.6）
?	λ轻链	4（11.2）
β2微球蛋白≥5.5 mg/l[例（%）]		14（38.9）

项目		?
年龄（岁，±s）		72.0±2.4
性别[例（%）]		?
?	男	23（63.9）
?	女	13（36.1）
重链类型[例（%）]		?
?	IgG	16（44.3）
?	IgA	12（33.3）
?	IgD	2（5.6）
轻链类型[例（%）]		?
?	κ轻链	2（5.6）
?	λ轻链	4（11.2）
β2微球蛋白≥5.5 mg/l[例（%）]		14（38.9）

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