The theoretical and technological framework in the field of orthopedic rehabilitation is highly complex, presenting significant challenges for rehabilitation professionals in acquiring the necessary knowledge, and to some extent, impacting the efficiency and effectiveness of clinical practice. Therefore, constructing a systematic clinical approach and achieving the integration and simplification of the knowledge framework is of substantial clinical importance. This paper introduces the CEST clinical approach for orthopedic rehabilitation, proposed by the Sixth People’s Hospital of Shanghai. Centered on clinical assessment, rehabilitation phases, and rehabilitation techniques, this approach adopts a systematic and modular design, organically integrating these three core components, thereby providing important theoretical foundation and practical pathways for achieving both individualized and standardized orthopedic rehabilitation.