Preliminary study on the difference of cartilage gene expression between weight-bearing joints and non-weight-bearing joints

doi:10.3877/cma.j.issn.2096-0263.2021.01.001

Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition) ›› 2021, Vol. 07 ›› Issue (01): 2-3. doi: 10.3877/cma.j.issn.2096-0263.2021.01.001

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• Research Letters • Previous Articles Next Articles

Preliminary study on the difference of cartilage gene expression between weight-bearing joints and non-weight-bearing joints

Tianrui Wang¹, Chenghao Yu¹, Zewen Sun¹, Jinbo Li², Haibo Zhao¹, Tianyu Li¹, Junqiang Xue³, Wei Chen⁴, Yingze Zhang⁵^,^†(), Tengbo Yu¹^,^†()

^1. Department of Orthopaedic Surgery, Affiliated Hospital of Qingdao University, Qingdao 266555, China
^2. Institute of medicine and health, Hebei Medical University, Shi Jiazhuang 050051, China; Orthopaedic Institute of Hebei Province, Shijiazhuang 050051, China
^3. Department of rehabilitation medicine, Affiliated Hospital of Qingdao University, Qingdao 266555, China
^4. Orthopaedic Institute of Hebei Province, Shijiazhuang 050051, China; Department of Orthopaedics Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
^5. Orthopaedic Institute of Hebei Province, Shijiazhuang 050051, China; Department of Orthopaedics Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China; NHC Key Laboratory of Intelligent Orthopeadic Equipment, Shijiazhuang 050051, China

Received:2020-12-21 Online:2021-02-05 Published:2021-04-25
Contact: Yingze Zhang, Tengbo Yu

Abstract

Abstract:

Articular cartilage is a layer of dense connective tissue that covers the surface of the joint. It has excellent lubricating properties and elasticity. It plays an important role in absorbing load distribution and alleviating joint shock. Our team collected the knee and shoulder articular cartilage of fresh cadavers and performed gene sequencing, and found that there were differences in the expression of articular cartilage in different parts.

Key words: Articular cartilage, Gene expression, Weight bearing, Non-weight bearing

Tianrui Wang, Chenghao Yu, Zewen Sun, Jinbo Li, Haibo Zhao, Tianyu Li, Junqiang Xue, Wei Chen, Yingze Zhang, Tengbo Yu. Preliminary study on the difference of cartilage gene expression between weight-bearing joints and non-weight-bearing joints[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2021, 07(01): 2-3.

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1	Shkhyan, R., et al., Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Annals of the rheumatic diseases, 2018. 77(5): p. 760-769.
2	Hong, E. and A. Reddi, MicroRNAs in chondrogenesis, articular cartilage, and osteoarthritis: implications for tissue engineering. Tissue engineering. Part B, Reviews, 2012. 18(6): p. 445-53.
3	Athanasiou, K., et al., Harnessing biomechanics to develop cartilage regeneration strategies. Journal of biomechanical engineering, 2015. 137(2): p. 020901.

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