To analyze the imaging features of desmoplastic fibroma of bone (DFB) and summarize its imaging diagnosis characters and differential diagnosis.

Retrospectively analyzed the X-ray, CT and MRI of 13 cases of DFB were confirmed by pathology from January 2002 to October 2019, and analyzed the imaging findings, including the location of the tumor, the destruction of the bone, and the bone of density in the lesion, characteristics of magnetic resonance signals and range of encroachment.

There were 7 males and 6 females, aged from 2-52 years old, more common in adolescents under 30 years old. 8 cases occurred at long bone, 3 cases occurred at sacrum and 1 case of vertebra and calcaneus. DFB is common in the metaphysis of long bones, and it can involve the diaphysis and epiphysis. There were 6 cases of loofah cyst type, 3 cases of osteolytic type, 3 cases of mixed type, and 1 case of parabone type. CT value is 30-60 Hu in the lesion area (6 cases CT value>45 Hu). 5 cases showed low mixed signals on T1WI and high mixed signals on T2WI, and showed low signals on T1WI and T2WI in the region. 3 cases showed Homogeneous low signal on T1WI and high signal on T2WI. 9 patients had soft tissue lumps.

DFB is a rare tumor with strong local aggressiveness, the loofah cyst type was more common in DFB, the low signals on T1WI and T2WI in the lesion, which are helpful for diagnosis and differentiate diagnosis of the disease.