The clinicopathological and prognosis of elderly patients lung cancer with bone metastases

doi:10.3877/cma.j.issn.2096-0263.2019.05.007

Abstract

Abstract:

Objective

To analyze the features and prognosis of elderly patients lung cancer with bone metastases.

Methods

The clinical-pathological data of elderly patients lung cancer with bone metastases were retrospectively collected. Gender, pathological type, location of tumors, smoking status, the primary focus operation, the alkaline phosphatase (ALP), number of bone metastases, radiotherapy or chemotherapy status and TNM stage were recorded. The log-rank tests were performed to compare survival curves. Multivariate analyses were conducted to identify significant independent prognostic factors for the prognosis.

Results

The average survival time of elderly patients lung cancer with bone metastases was 12 months. Univariate analysis showed significant relationships between the OS and the pathological type (χ²=4.178, P=0.041), the primary focus operation (χ²=7.980, P=0.005), the alkaline phosphatase (ALP) (χ²=6.814, P=0.009), the number of bone metastases (χ²=13.592, P<0.001) and the stages (χ²=10.060, P=0.018). Multivariate analysis results demonstrated ALP (HR=2.345, P=0.002) and the number of bone metastases (HR=1.987, P=0.001) were independent prognostic factors.

Conclusion

The prognosis of elderly lung cancer patients with bone metastases was poor, ALP and the number bone metastases can predict the prognosis.

Key words: Aged, Lung neoplasms, Alkaline phosphatase, Bone metastasis

Yunfan Ti, Jingwei Lu, Duo Yu, Bin Xu, Jianning Zhao, Guojing Sun. The clinicopathological and prognosis of elderly patients lung cancer with bone metastases[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2019, 05(05): 279-283.

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Figures/Tables 4

References 15

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项目		例数(%)	平均生存时间（月）	χ²值	P值
性别				0.521	0.470
	男	55(60)	11.7
	女	36(40)	12.4
病理类型				4.178	0.041
	腺癌	49(54)	10.7
	鳞癌	42(46)	13.1
肿瘤大体位置				0.414	0.520
	周边	66(73)	12.9
	中央	25(27)	12.4
吸烟史				0.150	0.699
	是	38(42)	13.4
	否	53(68)	11.9
原发灶是否手术				7.980	0.005
	是	43(47)	14.7
	否	48(53)	9.8
ALP(U/L)				6.814	0.009
	<150	24(26)	15.4
	≥150	67(74)	8.7
骨转移灶数目
	单发	51(56)	14.4	13.592	<0.001
	多发	40(44)	10.9
放疗				0.065	0.799
	是	48(53)	12.8
	否	43(47)	11.8
化疗				0.001	0.996
	是	50(55)	12.4
	否	41(45)	11.9
TNM分期				10.060	0.018
	I	9(10)	23.1
	Ⅱ	20(22)	17.5
	Ⅲ	25(27)	13.2
	Ⅳ	37(41)	7.8

项目		例数(%)	平均生存时间（月）	χ²值	P值
性别				0.521	0.470
	男	55(60)	11.7
	女	36(40)	12.4
病理类型				4.178	0.041
	腺癌	49(54)	10.7
	鳞癌	42(46)	13.1
肿瘤大体位置				0.414	0.520
	周边	66(73)	12.9
	中央	25(27)	12.4
吸烟史				0.150	0.699
	是	38(42)	13.4
	否	53(68)	11.9
原发灶是否手术				7.980	0.005
	是	43(47)	14.7
	否	48(53)	9.8
ALP(U/L)				6.814	0.009
	<150	24(26)	15.4
	≥150	67(74)	8.7
骨转移灶数目
	单发	51(56)	14.4	13.592	<0.001
	多发	40(44)	10.9
放疗				0.065	0.799
	是	48(53)	12.8
	否	43(47)	11.8
化疗				0.001	0.996
	是	50(55)	12.4
	否	41(45)	11.9
TNM分期				10.060	0.018
	I	9(10)	23.1
	Ⅱ	20(22)	17.5
	Ⅲ	25(27)	13.2
	Ⅳ	37(41)	7.8

项目	回归系数	标准误	自由度	P值	相对危险度	95.0% CI
项目	回归系数	标准误	自由度	P值	相对危险度	上部	下部
病理类型	-1.071	0.592	1	0.070	0.343	0.107	1.093
原发灶是否手术	-0.448	0.797	1	0.574	0.639	0.134	1.765
ALP	2.506	0.815	1	0.002	2.345	1.234	3.479
骨转移灶数目	1.7008	0.533	1	0.001	1.987	1.365	4.876
TNM分期	0.682	0.399	1	0.087	1.977	0.905	2.354

项目	回归系数	标准误	自由度	P值	相对危险度	95.0% CI
项目	回归系数	标准误	自由度	P值	相对危险度	上部	下部
病理类型	-1.071	0.592	1	0.070	0.343	0.107	1.093
原发灶是否手术	-0.448	0.797	1	0.574	0.639	0.134	1.765
ALP	2.506	0.815	1	0.002	2.345	1.234	3.479
骨转移灶数目	1.7008	0.533	1	0.001	1.987	1.365	4.876
TNM分期	0.682	0.399	1	0.087	1.977	0.905	2.354

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