Research progress of cellular senescence in bone metabolism and degenerative diseases

doi:10.3877/cma.j.issn.2096-0263.2023.02.008

Abstract

Abstract:

Cellular senescence refers to the irreversible cell cycle arrest process of cells, which is one of the focus in disease research in recent years. The main cause of cellular senescence is the activation of the tumor suppressor gene p16, p21 or p53 caused by DNA damage or epigenetic changes, resulting in growth arrest and the senescence-associated secretory phenotype, which leads to the release of inflammatory factors and extracellular matrix degradation proteases or hydrolases. Evidences have indicated that cellular senescence is important in maintaining normal embryonic development and mediating bone diseases in aging. Studies have shown that the clearance of senescence cells help delay the progression of age-related diseases in bone such as osteoarthritis and osteoporosis. Here, we reviewed recent studies on cellular senescence and SASP, and summarized the literature on the beneficial and adverse role of cellular senescence in different physiological stages. We also discussed the role of cellular senescence in maintaining the homeostasis of musculoskeletal system and mediating age-related degenerative bone and joint disorders. Although research on cellular senescence has made some progress, there are still some limitations. The purpose of this literature review is to provide a general picture on cellular senescence on bone development and bone-related diseases and to further facilitate understanding of the molecular mechanism of cell senescence and provide theoretical basis and ideas for understanding bone development as well as preventing degenerative bone and joint diseases from the cellular senescence perspective.

Key words: Cellular senescence, Senescence-associated secretory phenotype, Bone development, Bone disease

Xiaonan Liu, Bin Yu. Research progress of cellular senescence in bone metabolism and degenerative diseases[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2023, 09(02): 113-119.

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